Progesterone is one of the most important hormones in the body. It is a hormone that is present, along with its receptor sites, in both sexes, from fetal life until death.

The Benefits of Progesterone Cream:

The most efficacious and safest way to protect the endometrium is with topical progesterone.

Breast cancer will be diagnosed in one out of every eight women while uterine cancer occurs in only one out of every 3,700 women. Uterine cancer rates are currently 27 cases per 100,000 women.¹ A woman between the age of 45 to 65 years, is more than twice as likely to die from cancer than heart disease. Breast cancer is the leading cause of death in women 45-65 years old, while uterine cancer ranks much lower in the seventh position.²

Progesterone is probably best known as an anti-estrogen hormone. Estrogen can in some ways be considered a toxic hormone. It is responsible for causing cramps and PMS in women, as well as fibroids, endometriosis, fibrocystic disease of the breast, and PCOS. It is also likely responsible for menstrual migraines, asthma, gallbladder disease, and cellulite. As a lipogenic (fat-creating) hormone, it puts on fat around the hips, buttocks, and thighs. It is largely responsible for morning sickness that often occurs during the first three months of pregnancy. In addition, estrogen is linked to six different cancers in women - the breast, uterus, ovaries, vagina, cervix. It may also be the cause of breast cancer and prostate cancer in men. 

Anti-insulin effects
Another major benefit of progesterone cream is the effect it has on insulin. It appears to block the effect of insulin, possibly by blocking insulin receptor sites on cells. As a result, utilizing progesterone cream prevents the occurrence of hypoglycemia which is often found after eating, or between 3 and 4 PM, and also when people are driving. These are the classic times that people can experience sleepiness. 

This ability to prevent insulin from putting sugar into cells has important implications, such as possibly preventing type II diabetes. It may also be effective for preventing many of the complications of diabetes that can often be attributed to insulin, such as diabetic neuropathy. Another factor to consider is that insulin is the hormone that puts on fat around the middle. This is especially noticeable in men after the age of 50, which is the age they stop producing Progesterone.

Anti-adrenaline effects
A third major area demonstrating the importance of progesterone is that it helps to block the effects of adrenaline. It may do this by blocking adrenaline receptor sites. Those people who have high levels of adrenaline will often feel relaxed within 2 to 3 minutes of applying progesterone cream, and will also be able to focus better. 

This ability to help control adrenaline makes progesterone a true wellness hormone. In women, the largest areas of progesterone receptor sites are in the limbic area of the brain. This is the part of the brain that controls emotions. This particular area is the one most closely involved with violence and rage when there is excess adrenaline in the brain. This is clearly recognized in a condition called PMDD - premenstrual dysphoric disorder - which is found in about 5% of women who are menstruating. It is manifested by severe mood swings and severe anger issues, usually occurring 10 days out of the month.  Because of its ability to help control adrenaline, one can see how important progesterone can be for a condition like this. 

Adrenaline is known as the “fight or flight” hormone. Excess levels can result in anger, road rage, insomnia, restless leg syndrome, and teeth grinding. When anger is internalized, it can lead to depression, anxiety, fibromyalgia, IBS, as well as other problems. As a neurotransmitter in the brain, adrenaline causes the mind to race which can lead to problems with focusing – i.e. ADHD or brain fog. In more extreme cases, it can result in PTSD, bipolar disorder, or autism. 

Excess adrenaline gives people an urge to urinate, resulting in a condition often referred to as an overactive bladder. Along these same lines, adrenaline is responsible for a condition called chronic interstitial cystitis, a devastating condition manifested by severe bladder pain 24 hours a day. It also causes bedwetting in children. 

Other conditions caused by excess adrenaline include: hyperemesis gravidarum (a condition manifested by vomiting throughout all nine months of pregnancy), leg cramps at night, hot flashes, elevated blood pressure, cold hands and feet, cyclical vomiting syndrome, TMJ, ringing in the ears and headaches.

In addition, there are a number of other conditions that can be helped as well. For example, it may be used to help infertile women get pregnant, it may prevent or treat postpartum depression, and it may help eliminate diabetic neuropathy. Progesterone is also the treatment of choice for traumatic brain injuries.

Progesterone and Weight Loss
Concerns about weight are exceptionally common. Perhaps the most frequent unrecognized cause of weight gain can occur when people have excess adrenaline. In order to understand this, it is necessary to understand why the body is producing excess adrenaline. Thousands of years ago, the only time the body released adrenaline was during periods of danger. As soon as the danger passed, the body immediately stopped producing the adrenaline. Nowadays, however, people are often producing excess adrenaline all day and all night even while they are not in danger. The reason for this is that the body is using adrenaline to raise sugar levels for the brain via a process called gluconeogenesis.

Many people do not realize that the brain utilizes more sugar than any other part of the body, and that the brain cannot function without it. When sugar is taken away from the brain, the brain falls asleep. From a survival standpoint, the body always wants to make sure the brain can function. Because of this, anytime the body detects that the brain has run out of fuel it puts out adrenaline to help refuel the brain by raising sugar levels. People that toss and turn at night, or grind their teeth, or get up to urinate, are probably having issues caused by excess adrenaline. If these people wind up producing more sugar than they can burn up, the excess sugar winds up being stored as fat inside fat cells. In other words, they are gaining weight while they're sleeping.

From a weight standpoint, progesterone cream can benefit in a number of ways. It not only blocks adrenaline, it also helps to prevent the production of adrenaline. In addition, it blocks insulin, the hormone that creates fat around the middle.

Compared to estrogen, which is a lipogenic (fat-creating) hormone, progesterone is a thermogenic hormone that helps fat to burn. Another consideration is that progesterone helps the body manufacture thyroid, which is the hormone that controls metabolism in every cell of the body. 

The control of adrenaline and help with weight loss can only be accomplished by providing the brain with the fuel that it requires and also by using progesterone cream correctly. The two best fuels for the brain are green vegetables and coconut oil. 

Progesterone has numerous beneficial effects on both men and women, including contributing to the fight against a number of cancers. It is thought of as the anti-estrogen hormone as well as having anti-estrogen effects. Better yet, progesterone suppresses adrenaline and is well-named the "Happy Hormone" for its effects on mood and energy. 

Oral vs. Trandermal Cream

Many people ask whether they should use oral progesterone or cream. The definitive answer is the cream. When you take oral progesterone, it goes straight to the liver where it is converted into allopregnanolone - a derivative of progesterone. It is recognized on a lab test as progesterone, but is not able to attach to progesterone receptor sites. It causes drowsiness, which is why they recommend taking it at night. The cream, however, enters your bloodstream and bypasses the liver which explains why it is much more effective than oral progesterone.

References:

1. CDC – Uterine Cancer Incidence and Mortality — United States, 1999–2016 Weekly / December 7, 2018 / 67(48);1333–1338.
2. LCOD All Females by Age Group 2015 – Women’s Health – CDC. Centers for Disease Control and Prevention. https://www.cdc.gov/women/lcod/2015/all-females/index.htm. Accessed July 15, 2019.