DHEA - The Key to Wellbeing, a Well Known Secret

The hormone, dehydroepiandrosterone, or DHEA is a very important hormone that has not yet been plumbed by medical science, but we know enough about it to know it is absolutely essential for optimal health. 

Since the 1980’s, many research papers have been published on the multiple healthful functions DHEA performs in the body, including the following:

• Reduces fatigue

• Improves thinking

• Increased mood

• Promotes better sleep

• Improvement in sexuality

• Has anti-aging qualities

• Helpful with osteoporosis

• Improves blood vessel function and insulin sensitivity

• Boosts the immune system

• Helps reduce body fat

• Helps address auto-immune diseases 

These benefits are noticed after about four months of therapy.

DHEA will always be decreased in the menopause. A blood test (not saliva test) is the best way of knowing how much to use.

If it is below 100, it is fairly safe to start with 25 mg/ day. Over 100, start with 10 mg per day. If no test is available, you can perhaps start with 25 mg M-W-F.

When measuring DHEA levels, the proper lab test is the one that assesses DHEA-S, not DHEA.

What is DHEA?

DHEA serves as a precursor to male and female hormones. It is a prohormone and produced mainly by the adrenal glands, but also by the gonads, the brain, and the skin. It serves as a precursor to male and female hormones, and is also referred to as the parent hormone. 

Pregneneolone is the immediate precursor to DHEA as well as progesterone. Accordingly, it is referred to as the grandfather of all steroid hormones.  As a side note, when you take pregneolone, you have no control as to whether it will down regulate into DHEA or progesterone.  Because of this, I recommend taking DHEA and progesterone directly.

At one stage of life— during the teenage years—it is the most abundant steroid hormone in the body. DHEA levels decline in a straight line as we age. 

In fact, some believe that many of the manifestations of aging are caused by deficiencies in DHEA.

This hormone begins to appear in our bodies at age 5, peaks during our 20s, is at the 50 percent level at age 40, and between the ages of 60 and 80 declines to between 20 and 10 percent of peak levels. This definitive decrease is not seen with other hormones, and because of it, DHEA is considered the biological marker for aging: those people with the highest levels seem to have the greatest longevity. In fact, some believe that many of the manifestations of aging are caused by deficiencies in DHEA.

Administration of DHEA is associated with a remarkable increase in perceived physical and psychological well-being. People report increased energy, better sleep, a significant improvement in sexuality and in mood, along with a better ability to handle stress.

DHEA has been shown to enhance memory and mental acuity and to decrease depression. Administration of DHEA helps to boost the immune system, improves chronic fatigue syndrome, helps to reduce body fat, and helps address auto-immune diseases such as lupus, ulcerative colitis, and rheumatoid arthritis.

DHEA has its own receptor sites. It raises growth hormone levels and breaks down into testosterone, which may possibly be the reason for some of its benefits.

People with high levels of DHEA have lower incidences of Alzheimer’s and Parkinson’s disease. 

In a six-month placebo-controlled study, male patients with Alzheimer’s disease (AD) were randomized to DHEA 50 mg twice daily vs. placebo. At three months, the DHEA group showed a trend toward superior cognitive performance compared to the placebo group and this trend lasted until the end of the study (Wolkowitz et al 2003). In a small four-week open study, seven individuals with multi-infarct dementia who received daily intravenous administration of DHEA-S (the sulfated form of DHEA) (200 mg) exhibited significant increases in serum and cerebrospinal fluid levels of DHEA-S, improvements in activities of daily living and less frequent emotional disturbances (Azuma et al 1999). Sourced:  Psychology Today

Some consider a low DHEA level to be the most significant biological marker for breast cancer in premenopausal women.

DHEA and Men

In men, estradiol levels should be monitored while taking DHEA. Ideally, the estradiol level should not be higher than 20. If it is higher than this to begin with, I do not prescribe DHEA. If the level goes over 40 while the person is on DHEA, I cut back the dosage or the frequency of administration. It is important to discuss taking any supplements with your physician before starting. 

When levels of estrogen or testosterone are problematic, another approach is to use a different form of DHEA called 7-keto DHEA. This formulation does not convert into estrogen or testosterone. It can be obtained over the counter; the dosage is 100 mg per day.

DHEA and Stress

People who live with a lot of stress start to show lowered DHEA levels after a certain amount of time. Their adrenal glands become exhausted, and since the adrenal glands produce the majority of DHEA, their DHEA levels go way down. 

Progesterone, like DHEA, diminishes in people who live under constant stress. 

In summary, DHEA is considered the biological marker for aging, those people with the highest levels seem to have the greatest longevity. Administration of DHEA is associated with a remarkable increase in perceived physical and psychological well-being. These benefits are noticed after about four months of therapy. People report increased energy, better sleep, and a significant improvement in sexuality and in mood, along with a better ability to handle stress.

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The Platt Wellness Team is pleased to assist you with information about our products. Please know we are not licensed medical professionals and therefore cannot provide you with any medical advice or information. If you require medical advice or information please contact a medical or health care professional. Please remember the information contained in this email message is for informational purposes only. The statements in this email have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

Dr. Michael E. Platt has been a pioneer in the research and advancement of the therapeutic use of progesterone cream for use in managing adrenaline and hormonal imbalance. Dr. Platt is considered an important pioneer in observational, functional, alternative, and allopathic medicine focused on bio-identical hormones and adrenaline overload.  His three books “The Miracle of Bioidentical Hormones”, “Adrenaline Dominance” and “Platt Protocol” have received 11 literary awards.