Hey Doc:

So how do you use progesterone cream if you have insulin resistance? What do you do for insulin resistance?


Dear Rebecca

Insulin resistance is most commonly associated with type II diabetes. In this situation, a person’s insulin has trouble getting sugar into cells resulting in elevated blood sugars. In this situation you would want to use progesterone in the usual fashion by applying it about 1-3 minutes before eating. This would help control insulin levels as well as sugar level increases from adrenaline.

There is another type of insulin resistance that is not as well known. This is where there is insulin resistance in the brain, a situation that is called type III diabetes. In this case the insulin in the brain has a hard time putting sugar into brain cells. The consequence of this is that the body will be producing high levels of adrenaline in order to raise sugar levels for the brain. In addition, a more serious consequence is that this condition is a frequent predisposing factor to the development of Alzheimer’s.

In this particular situation, you would want to avoid using progesterone prior to eating since it can increase insulin resistance in the brain, and use the progesterone between meals to help control symptoms of excess adrenaline.At the same time, incorporate coconut oil into your meal plan to be used with every meal and at bedtime. The ketones from coconut oil can provide fuel for the brain and do not require insulin to get into the brain cells. Needless to say, coconut oil is the drug of choice for those people with Alzheimer’s. Perhaps the best way of determining if someone has type III diabetes is to observe whether a person’s adrenaline response increases after introducing progesterone before meals. The supplement of choice for this condition is berberine, 500 mg twice a day. The prescription drug of choice is metformin, about 850 mg twice a day.

Please call with additional questions.

Michael E. Platt, md