Why there is so much variation with doctors in regards to dosage and timing and for how long when it comes to progesterone?

Progesterone dosage recommendations

Q. A member in one of the facebook groups I follow regarding bio-identical hormones asked why there is so much variation with doctors in regards to dosage and timing and for how long when it comes to progesterone.  They cited a page from Dr. Lee's Hormone Balance Made Simple book.  This is what she highlighted seeking clarification from the group,  I thought it might be best to ask you your thoughts.  Thank you!

"We have heard tales of healthcare professionals and pharmacists recommending a 100mg daily dosage of progesterone cream.  This type of medical mismanagement is guaranteed to cause not just side effects, but serious hormonal imbalances, including a shutting down of hormone receptors''

"Chronically high doses of progesterone over many months eventually cause progesterone receptors to turn off, reducing its effectiveness.  Using excessive doses of progesterone can also cause the side effects listed below.  Not all women suffer from these side effects when they use excessive doses of progesterone, but eventually their symptoms will return."

I just thought it would be best to ask you, thank you!

Nicki Anderson


John Lee was under the mistaken impression that a woman produces 20 mg of progesterone a day.

In actuality, it is much higher. This is why he recommended using a 2% (20 mg per pump) progesterone once a day. That strength frequently attaches to estrogen receptor sites and acts like estrogen. It is not strong enough to effectively block estradiol. and certainly not strong enough to block adrenaline and insulin which require a 5% strength.

John Lee and I used to give talks at the same bio-identical hormone conferences before he died. We never saw eye to eye. Contrary to the information in his books, using a 5% progesterone cream does not shut down receptor sites, nor does it have any side effects.

A woman releases incredibly high levels of progesterone that the fetus gets exposed to during the last six months of pregnancy. Even those levels do not shut off receptor sites in the fetus or the mother.

In order to heal issues such as endometriosis, and fibroids, and PCOS, and inability to conceive, and prevent miscarriages. It is imperative to use a minimal dosage of 200 mg per day (800 mg for endometriosis).

What I am saying about progesterone cream does not apply to oral progesterone which is converted by the liver into a a different hormone called allopregnaneolone which has definite side effects and I never recommend oral progesterone.

The only serious side effect I have noted from progesterone - and this applies to any strength - is that it can cause a rapid increase in adrenaline levels in those people with Type III diabetes (insulin resistance in the brain). Unbeknownst to the medical system, this is actually the only test for this condition, which is a common precursor to developing Alzheimer's

disease. If people are made aware of this condition, they can actually prevent Alzheimer's by incorporating coconut oil and MCT oil into their meal plan which raise levels of ketones needed for the brain.

Dr. Michael E. Platt has been a pioneer in the research and advancement of the therapeutic use of progesterone cream for use in managing adrenaline and hormonal imbalance. Dr. Platt is considered an important pioneer in observational, functional, alternative, and allopathic medicine focused on bio-identical hormones and adrenaline overload.  His three books “The Miracle of Bioidentical Hormones”, “Adrenaline Dominance” and “Platt Protocol” have received 11 literary awards. 


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  • I had a very strange “atypical migraine” right at menopause and suffered from the migraine on and off and tinnitus after that. Then it got bad enough that I found out that I was reacting to foods with histamine in them. I had a migraine with pulsatile tinnitus every night and could not eat normally for over a year. Doctors either could not help or dismissed my symptoms. After some research (and trying everything else) I tried a progesterone cream from the drug store -but it did not work. Finally, a gynecologist prescribed 100mg oral progesterone and told me to take it before bed. It did not at help at all. Then I got the idea to take it in the morning. The migraines went way down in intensity and I could eat normally for a few hours. After that result (and some more research) I stopped taking the oral progesterone and ordered the Platt Wellness 5% Progesterone Cream. After using 3 times per day for a week the histamine intolerance is way down. I need to know if I need to take it before or after eating and if that really makes any difference and why. Also, I assume that after some period of time my progesterone level will be high enough that I can go back down to a maintenance dose. Any suggestions on how I should do this? Every doctor I go to about this has no idea and I get the feeling I am on my own with this.

    Beverly Klemme on
  • Hi, Dr. Platt:

    I believe that I have adrenaline dominance as I have most of the symptoms you’ve stated in your book. I just started taking the cream (5 days) and this is my question. I sometimes forget to take it and don’t realize until after I’ve eaten. Is it pointless to take it after I have ingested my meal? Should I go for seconds so that I can take the cream and then eat, albeit a small portion, again? Or should I just let it go and try to remember before the next meal?

    Also, how long does 3 oz of the cream last if I’m taking 4 times a day?

    Thank you so much for your help!


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  • I’m name is Michelle , I am 40 yo and I have been researching hips about t3 hormones . And this website and all the knowledge in it is nothing short of extraordinary! I am really glad I found it and I feel more confident about starting with a hormonal treatment, something that unfortunately the majority of doctors know little about .
    Thanks doc 🤗

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  • What are the side effects of allopregnanolone?

    mary lott on
  • Thank you Dr. Platt for all the education and help! From our last phone conversation, I added desiccated bovine thyroid to my daily routine and I feel SO MUCH better!!
    I recommend you ,your books and your products to all my friends, family and female clients!
    Thank you again
    Martha Almeida


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