The question often arises about whether progesterone cream should be cycled or used every day. All providers of progesterone cream recommend cycling the cream, skipping either the first week or first two weeks. I am probably the only exception because I recommend using it every day.
The reason for this is as follows: progesterone is felt to be an anti-estrogen hormone and helps to protect women (and men) from problems caused by estrogen. If this was the only function of progesterone then it would make sense to cycle it. However, what is not known is that progesterone also blocks insulin and adrenaline, two hormones that have unpleasant side effects. And unlike estrogen, they are released throughout the day every day.